Studying the building blocks of life

Yinfa Ma, Curators’ Teaching Professor of chemistry, and Honglan Shi, an associate research professor of chemistry, are working with colleagues at Clemson University to develop a microscopic fiber optic probe that can detect changes in a single cell. The work is funded through a $567,311 grant from the National Institute of General Medical Sciences of the National Institutes of Health.

Imagine a doctor’s needle that is only 2 to 5 microns in size. When inserted into a cell, the probe’s fluorescent nanomaterial-doped tip is used to detect either the cell’s pH change or corresponding temperature change.

When hit with a laser source attached to the probe, the six strands surrounding the central fiber detect changes in the cell’s reflected fluorescent signal. Researchers then calculate the ratio in two ways: one looks at the peak fluorescent intensity and the reference intensity; the other measures the decay time of the phosphorescence, which is then calculated and correlated with the pH or temperature values.

“Comprehensive understanding of a single cell in response to its biological environment and stimuli is becoming the foundation of many biomedical research fields, including drug development, nanotoxicity study, biomarker discovery, cancer diagnosis and treatment, and many other areas,” Ma says.

Around the Puck

By the numbers: Fall/Winter 2018

8,607 Students enrolled for the fall semester at Missouri S&T. Classes started Aug. 20. 91 Percentage of first-year freshmen who receive scholarships and financial aid.

[Read More...]

Making tornado alley safer

Growing up in northeast China, Guirong “Grace” Yan didn’t see many tornados in a country where the number of documented twisters is a fraction of those that hit the United States. But as her academic career took Yan to several postdoctoral fellowships and then faculty positions in Indiana, Missouri and Texas, the assistant professor of […]

[Read More...]

Living laboratory houses lead battery research

This past November, Missouri S&T installed two new advanced lead battery microgrid systems at the EcoVillage, a “living laboratory” that is home to S&T’s solar-powered homes.

[Read More...]

Partners for progress

An expansion of the partnership between Missouri S&T and Missouri State University will allow students to pursue a mechanical engineering degree on the Missouri State campus with courses taught by faculty from both institutions. Students began applying this fall. The program will begin in fall 2019.

[Read More...]

Chancellor search is underway

This past August, University of Missouri President Mun Choi announced the formation of a 23-member committee to lead a nationwide search for a chancellor at Missouri S&T.

[Read More...]